New research suggests that people who stop using popular slimming jabs like semaglutide or tirzepatide may regain shed pounds at a significantly accelerated pace than those who end traditional diet and exercise plans.
Findings released in a major medical journal points out that while overweight people often shed about a fifth of their body weight while using the jabs, the mass comes back at an average rate of 0.8 kg per month upon discontinuation.
"Users using such medications should be informed of the potential of fast rebound weight gain when the treatment is stopped," cautioned expert Dr. Susan Jebb.
This pace of recovery implies a return to starting weight within about a year and a half.
Comparing Approaches
The research, which reviewed dozens of trials involving thousands of patients, contrasted the results of these new drugs with other pills.
Researchers note that individuals who shed pounds through dieting usually have a less rapid creep back—around 0.1 kg a month—post-intervention.
Understanding the Quick Regain
Experts suggest the mode of action of the injections is key to understanding the heightened regain.
These medications imitate a body's own chemical called glucagon-like peptide-1, which moderates hunger.
"Long-term administration of GLP-1 concentrations far above than the body's typical production may cause the system to generate a reduced amount of its own natural hormone, and may also reduce sensitivity to its effects," explained Dr. Adam Collins, a nutrition researcher.
"Discontinuation of this medication means appetite is no longer kept in check, making binge eating far more likely."
An Ongoing Condition?
Health authorities advise the injections for people with obesity-related health risks, accompanied by recommended lifestyle changes.
Many experts say that, due to the significant potential of relapse, the treatment might need to be long-term.
This view is reinforced by pharmaceutical companies, who note that the results "highlight the long-term nature of excess weight," akin to managing diseases like high blood pressure.
User Accounts
Individuals who have come off the medication report a sudden resurgence of appetite.
"It was like something flipping and I was suddenly ravenous," described one woman.
This difficulty is worsened if users have not developed permanent dietary or behavioural changes during therapy.
Widespread Adoption
Figures indicate that a significant number of people in the UK have tried these injections in the last 12 months, with demand remaining high.
- Use is higher among females than men.
- The middle-aged age group shows the greatest level of interest.
- Many obtain the drugs through private prescriptions rather than the NHS.
Ultimately, experts caution that while GLP-1 drugs are effective tools for shedding pounds, they are not a magic fix and lasting health benefits likely depends on combined lifestyle changes.
